Our laboratory investigates the molecular and cellular mechanisms underlying aging and age-related neurodegenerative disorders. We use a multidisciplinary approach that combines in vivo models, including zebrafish (Danio rerio) and Caenorhabditis elegans, with advanced molecular biology, imaging, and bioinformatics tools.
A major focus of our work is to understand how genetic, epigenetic, and environmental factors interact to shape the aging brain. We examine alterations in neural cell populations—particularly microglia and glia–neuron interactions—and how these changes influence brain homeostasis, plasticity, and vulnerability to disease. Our research also extends to modeling amyloidosis, Parkinson’s disease, and other proteinopathies to explore the cellular responses that drive neurodegeneration.
We employ high-throughput transcriptomics, proteomics, and imaging-based phenotyping to identify biomarkers and pathways linked to aging and pathology. These insights are integrated with behavioral and functional analyses to establish mechanistic connections between molecular changes and organismal outcomes.
Ultimately, our goal is to uncover targets for interventions that can preserve cognitive function, delay the onset of neurodegenerative diseases, and improve healthspan. By bridging basic research with translational perspectives, we aim to contribute to the development of strategies that promote healthy brain aging across the lifespan.
